Alberto Ferri

Nuclear DNA damage is a primary driver of mitochondrial dysfunction in C9ORF72 ALS/FTD

This study shows that nuclear DNA damage directly causes mitochondrial dysfunction in C9ORF72 ALS/FTD by triggering a DNA damage response that depletes NAD+ and impairs mitochondrial bioenergetics.

Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease

This study investigates sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons, revealing sex-biased impacts on neuronal activity, mitochondrial function, and non-motor Parkinson's symptoms.

Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis.

The paper investigates changes in brown adipose tissue and its extracellular vesicles in an ALS mouse model, showing their impact on myoblast homeostasis and muscle atrophy.

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS)

This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.