Debashree Ray

This paper introduces PGS-TRI, a framework to estimate direct and indirect polygenic effects and gene-environment interactions in case-parent trio studies, applied to autism and orofacial clefts.

This study identifies pleiotropic variants and trait-specific susceptibility variants using GWAS data from 116 traits, revealing widespread pleiotropy and unique genetic contributions to specific traits.

This paper benchmarks statistical methods for analyzing parent-child dyads in genetic association studies, finding that some methods better control type I error and power compared to others.

This study identifies 5 novel genetic loci associated with physical activity using 27 accelerometry-derived phenotypes from 88,411 UK Biobank participants.

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

Exome sequencing in Finnish populations identifies rare trait-associated alleles with higher frequencies and geographical clustering, revealing 30 novel associations with quantitative traits.