This study identifies novel genetic risk loci for pancreatic ductal adenocarcinoma in African ancestry individuals through admixture mapping and GWAS.

medRxiv · Apr 22, 2026 · PreprintGenetic & Genomic Medicine

A hepatitis B virus (HBV) sequence variation graph improves sequence alignment and sample-specific consensus sequence construction for genetic analysis of HBV

Dylan Duchen, Steven J. Clipman, Candelaria Vergara, Chloe L. Thio, David L. Thomas, Priya Duggal, Genevieve L. Wojcik

This paper shows that using a genome graph instead of a linear reference improves HBV sequence alignment and sample-specific consensus sequence construction.

PLoS ONE · Apr 26, 2024Peer-reviewedGenomics

Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants

Laura Chen, Rebecca M. Munday, Rashidul Haque, Dylan Duchen, Uma Nayak, Poonum S. Korpe, Alexander J. Mentzer, Beth D. Kirkpatrick, Genevieve L. Wojcik, William A. Petri, Priya Duggal

This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

Open Forum Infectious Diseases · Feb 29, 2024Peer-reviewedGenetic & Genomic Medicine

Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants

Guillaume Butler‐Laporte, Kathryn Auckland, Zannatun Noor, Mamun Kabir, Masud Alam, Tommy Carstensen, Genevieve L. Wojcik, Amanda Yoon-Yee Chong, Cristina Pomilla, Janelle Annette Noble, Shana L. McDevitt, Gaby P. Smits, Susan Wareing, Fiona R.M. van der Klis, Katie JM Jeffery, , Alexander J. Mentzer

The paper identifies HLA variants associated with HBV vaccine response in Bangladeshi infants and links them to vaccine escape mechanisms.

medRxiv · Jun 26, 2023 · PreprintGenetic & Genomic Medicine

Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common controls

Dylan Duchen, Candelaria Vergara, Chloe L. Thio, Prosenjit Kundu, Nilanjan Chatterjee, David L. Thomas, Genevieve L. Wojcik, Priya Duggal

This study shows that using population-based common controls in GWAS of infectious diseases can lead to biased effect estimates and spurious associations due to unaccounted pathogen exposure.

medRxiv · Jul 14, 2022 · PreprintGenetic & Genomic Medicine

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies

Debashree Ray, Candelaria Vergara, Margaret A. Taub, Genevieve L. Wojcik, Christine Ladd‐Acosta, Terri H. Beaty, Priya Duggal

This paper benchmarks statistical methods for analyzing parent-child dyads in genetic association studies, finding that some methods better control type I error and power compared to others.

Genetic Epidemiology · Apr 22, 2022Peer-reviewedGenetics

Antiviral Antibody Epitope Selection is a Heritable Trait

Thiagarajan Venkataraman, Cristian Valencia, Massimo Mangino, William R. Morgenlander, Steven J. Clipman, Thomas Liechti, Ana Valencia, Paraskevi Christofidou, Tim D. Spector, Mario Roederer, Priya Duggal, H. Benjamin Larman

The paper identifies heritable antibody epitopes and genetic loci associated with EBV immune responses and viral load control using twin and SNP-genotyped data.

bioRxiv · Mar 25, 2021 · PreprintGenetics

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

Marissa LoPresti, David B. Beck, Priya Duggal, Derek A. T. Cummings, Benjamin D. Solomon

This paper reviews host genetic factors associated with coronavirus susceptibility in humans and animals, identifying significant loci and highlighting limitations in current studies.

The American Journal of Human Genetics · Aug 12, 2020Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of cryptosporidiosis in infants implicates PRKCA

Genevieve L. Wojcik, Poonum S. Korpe, Chelsea S. Marie, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Abu Syed Golam Faruque, Rashidul Haque, William A. Petri, Priya Duggal

This paper conducts a GWAS to identify genetic variants associated with symptomatic cryptosporidiosis in infants, finding a strong association with an intronic SNP in PRKCA.

mBio · Feb 3, 2020Peer-reviewedGenetics

Genome-Wide Association Study Reveals Genetic Link Between Diarrhea-Associated Entamoeba histolytica Infection And Inflammatory Bowel Disease

Genevieve L. Wojcik, Chelsea S. Marie, Mayuresh M. Abhyankar, Nobuya Yoshida, Kôji Watanabe, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Rashidul Haque, George C. Tsokos, William A. Petri, Priya Duggal

This study identifies genetic variants associated with Entamoeba histolytica infection and links them to inflammatory bowel disease susceptibility.

mBio · Sep 18, 2018Peer-reviewedGenetics

Genotype Imputation Performance of Three Reference Panels Using African Ancestry Individuals

Candelaria Vergara, Margaret M. Parker, Liliana Franco, Michael H. Cho, Ana Valencia, Terri H. Beaty, Priya Duggal

This study compares genotype imputation performance of three African ancestry reference panels in African American cohorts, finding 1000G provides the highest imputation quality and coverage.

Human Genetics · Apr 1, 2018Peer-reviewedGenetics

Household Transmission Study of Cryptosporidiosis in Bangladesh

Poonum S. Korpe, Carol Gilchrist, Cecelia Burkey, Emtiaz Ahmed, Vikram Madan, Rachel Castillo, Shahnawaz Ahmed, Tuhinur Arju, Masud Alam, Mamun Kabir, William A. Petri, Rashidul Haque, A.S.G. Faruque, Priya Duggal

This study investigates household transmission of Cryptosporidium in Bangladesh, finding higher secondary infection rates in urban areas compared to rural regions.

bioRxiv · Feb 23, 2018 · PreprintMicrobiology