Joanna Melia

This study analyzes TCR repertoires from ulcerative colitis patients over time, identifying Vβ gene usage and K-mer enrichment differences between flare and remission states.

The paper integrates proteomics data from Olink and SomaScan to identify pQTLs and develop a resource for transcriptome and proteome-wide association studies, with applications to inflammatory bowel disease.

This study analyzes the TCR repertoire in UC patients over time, finding most do not share persistent clones, while a subset has persistent clones linked to more active disease.

This study shows that a ZIP8 mutation causes aberrant N-glycosylation in Crohn's disease, which can be treated with N-acetylglucosamine supplementation.

The paper establishes a Zip8 393T-knock-in mouse model and reports baseline behavioral and anatomical findings, showing subtle cognitive defects in male homozygous mice but no major differences from wild-type.