Author

Ruxian Lin

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Mark DonowitziD· 2 shared Varsha SinghiD· 2 shared Caitlin M. TressleriD· 1 shared Chung‐Ming TseiD· 1 shared Dario BoffelliiD· 1 shared Hugo R. de JongeiD· 1 shared Huimin YuiD· 1 shared Jianbo YangiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

Mark DonowitzORCID

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3 papers

Recent·Most cited

Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes

Varsha Singh, Ruxian Lin, Laxmi Sunuwar, Jianbo Yang, Mark Donowitz, Rafiquel I. Sarker

This study identifies distinct mechanisms of NHE3 regulation in type 1 and type 2 diabetes, showing SNX17 loss in T1D reduces NHE3 stability while T2D involves transcriptional downregulation in the colon.

American Journal of Physiology-Cell Physiology · Sep 10, 2025Peer-reviewedPhysiology

Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.

Rong Yan, Zixin Zhang, Hugo R. de Jonge, Ruxian Lin, Huimin Yu, Rafiq Sarker, Dario Boffelli, Rachel K. Zwick, Ophir D. Klein, Chung‐Ming Tse, Mark Donowitz, Varsha Singh

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

iScience · Apr 17, 2025Peer-reviewedPhysiology

Aberrant N-glycosylation is a therapeutic target in carriers of a common and highly pleiotropic mutation in the manganese transporter ZIP8

Vartika Tomar, John Kang, Ruxian Lin, Steven R. Brant, Mark G. Lazarev, Caitlin M. Tressler, Kristine Glunde, Natasha Elizabeth Zachara, Joanna Melia

This study shows that a ZIP8 mutation causes aberrant N-glycosylation in Crohn's disease, which can be treated with N-acetylglucosamine supplementation.

bioRxiv · Jun 28, 2024 · PreprintGenomics