Jianxiong Guo

This study generates 10-gene-edited pigs that reduce immune rejection and zoonotic risks for xenotransplantation, showing improved survival in non-human primate recipients.

This study investigates the effects of leptin overexpression in transgenic pigs on reproductive performance, revealing delayed puberty, irregular estrous cycles, and reduced breeding efficiency due to hormonal imbalances and ovarian dysfunction.

The paper edits four genes in donor pigs and transplants their kidneys into monkeys, showing reduced immune rejection and successful graft survival.

The paper modifies pigs' genomes to create organs compatible with human transplantation by inactivating PERVs and engineering immune-related genes.