Author

Luhan Yang

ORCID 0000-0002-5501-1423Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

George McDonald ChurchiD· 2 shared Yinan Kan· 2 shared Adrian Briggs· 1 shared Birgitte RegenbergiD· 1 shared Daniel Goodman· 1 shared David CoxiD· 1 shared Deling JiaoiD· 1 shared Dharmendra B. Goswami· 1 shared

Activity by Year

2016-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersSynthetic Biology

George McDonald ChurchORCID

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3 papers

Recent·Most cited

Synthetic BiologyNature Biomedical EngineeringPeer-reviewedSep 21, 2020

Extensive Mammalian Germline Genome Engineering

Yanan Yue, Weihong Xu, Yinan Kan…·Luhan Yang

The paper modifies pigs' genomes to create organs compatible with human transplantation by inactivating PERVs and engineering immune-related genes.

176 citationstop 1%

plant (other)whole-genome sequencing

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GenomicsNucleic Acids ResearchPeer-reviewedAug 22, 2018

Circularization of genes and chromosome by CRISPR in human cells

Henrik Devitt Møller, Lin Lin, Xi Xiang…·Yonglun Luo

This study demonstrates CRISPR/Cas9 can generate extrachromosomal circular DNA and ring chromosomes in human cells, enabling new tools for genetic engineering and disease modeling.

117 citationstop 4%

humanexperimental assay

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BioengineeringNature CommunicationsPeer-reviewedNov 2, 2016

Genome Editing With Targeted Deaminases

Luhan Yang, Adrian Briggs, Wei Leong Chew…·George Church

This paper introduces targeted deaminases for site-specific C-to-T genomic edits without DNA cleavage, achieving 13% efficiency in E. coli and 2.5% in human cells with reduced toxicity.

DOI 10.1038/ncomms13330

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