Author

Yixiao Cheng

The University of Texas MD Anderson Cancer CenterORCID 0009-0002-3864-3733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Peter Van LooiD· 2 shared Yidan PaniD· 2 shared Adrienne Margaret FlanaganiD· 1 shared Alexander SteiniD· 1 shared Annelien VerfaillieiD· 1 shared Baoyu JiaiD· 1 shared Chang Yang· 1 shared Charles SwantoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenomics

Peter Van LooORCID

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3 papers

Recent·Most cited

Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour

Haixi Yan, Jonas Demeulemeester, Annelien Verfaillie, Yixiao Cheng, Yidan Pan, Cristina Cotobal, Sophia Ward, Alexander Stein, Tom Lesluyes, Tom L. Kaufmann, Roland F. Schwarz, Thierry Voet, Charles Swanton, Simone Zaccaria, Adrienne Margaret Flanagan, , Peter Van Loo

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

bioRxiv · Aug 21, 2026 · PreprintGenomics

Arborist: Prioritizing Bulk DNA Inferred Tumor Phylogenies via Low-pass Single-cell DNA Sequencing Data

Leah L. Weber, Chi Yin Ching, Christopher P. Ly, Yidan Pan, Yixiao Cheng, Chunxu Gao, Peter Van Loo

Arborist improves tumor phylogeny reconstruction by integrating bulk DNA-seq and low-pass scDNA-seq data, outperforming existing methods on simulated and biological datasets.

bioRxiv · Feb 28, 2026 · PreprintBioinformatics

Unraveling the impact of hyperleptinemia on female reproduction: Insights from transgenic pig model

Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, , Hong‐Jiang Wei

This study investigates the effects of leptin overexpression in transgenic pigs on reproductive performance, revealing delayed puberty, irregular estrous cycles, and reduced breeding efficiency due to hormonal imbalances and ovarian dysfunction.

Biological Research · Sep 3, 2024Peer-reviewedGenetics