Muhammad Ameen Jamal

This study generates genetically identical mammalian oocytes using parthenogenetic double-haploid embryonic stem cells and blastocyst complementation, producing viable and fertile mice with epigenetic defects.

The paper shows that efficient reprogramming in SCNT occurs exclusively in the epiblast, enabling cloned mouse generation through a lineage-specific mechanism.

This study generates 10-gene-edited pigs that reduce immune rejection and zoonotic risks for xenotransplantation, showing improved survival in non-human primate recipients.

The paper edits 8 genes in pigs to reduce immune rejection and tests their effectiveness in xenotransplantation to non-human primates.

This study investigates the effects of leptin overexpression in transgenic pigs on reproductive performance, revealing delayed puberty, irregular estrous cycles, and reduced breeding efficiency due to hormonal imbalances and ovarian dysfunction.

The paper edits four genes in donor pigs and transplants their kidneys into monkeys, showing reduced immune rejection and successful graft survival.