DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
Giovanna Mantica, Aditi Vedi, Amos Tuval, Hector Huerga Encabo, Daniel Hayler, Aleksandra Krzywon, Emily Mitchell, William G. Dunn, Tamir Biezuner, Hugo P. Bastos, Kendig Sham, Antonella Santoro, Joe Lee, Nick Williams, Adi Danin, , Elisa Laurenti
This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.
bioRxiv · Oct 8, 2025 · PreprintCell Biology