Tamir Biezuner

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

The paper compares seven single-cell whole genome amplification kits using targeted sequencing to evaluate genome coverage, reproducibility, and error rates across a large cohort of human cells.

This paper introduces a method to reconstruct human cell lineages using STR mutations and demonstrates its application on melanoma and DU145 cell lines.

The paper identifies microhomology-mediated end joining (MMEJ) as the mechanism behind recurrent deletions in myeloid malignancies and shows that these deletions occur in multipotent hematopoietic stem cells.

The paper develops a Markov model to predict STR stutter noise from direct in vitro measurements, improving genotyping accuracy in single-cell and targeted-enrichment contexts.