The paper introduces an EPD assay to study human HSC lineage commitment and identifies IL-33 as a regulator of megakaryopoiesis by activating the MAPK pathway.

bioRxiv · Sep 3, 2026 · PreprintCell Biology

DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells

Giovanna Mantica, Aditi Vedi, Amos Tuval, Hector Huerga Encabo, Daniel Hayler, Aleksandra Krzywon, Emily Mitchell, William G. Dunn, Tamir Biezuner, Hugo P. Bastos, Kendig Sham, Antonella Santoro, Joe Lee, Nick Williams, Adi Danin, , Elisa Laurenti

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

bioRxiv · Oct 8, 2025 · PreprintCell Biology

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

Matthew Williams, Xiaonan Wang, Hugo P. Bastos, Gabriela Grondys-Kotarba, Carys Johnson, Nicole Mende, Emily F Calderbank, Michelle Wantoch, Hyun Jung Park, Qin Wu, 金舒晟, Giovanna Mantica, Rebecca Hannah, Nicola K. Wilson, Dean C. Pask, , Anthony Richard Green

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

Blood Advances · Oct 7, 2024Peer-reviewedCell Biology