Author

Daniel Hayler

Wellcome/MRC Cambridge Stem Cell Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Elisa LaurentiiD· 3 shared Emily F. CalderbankiD· 2 shared Emily MitchelliD· 2 shared George S. VassiliouiD· 2 shared Giovanna ManticaiD· 2 shared Hugo P. BastosiD· 2 shared Jyoti NangaliaiD· 2 shared Kendig ShamiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Elisa LaurentiORCID

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Author profile →

3 papers

Recent·Most cited

Modelling human haematopoietic stem cell commitment ex vivo identifies IL-33 as a regulator of megakaryopoiesis

Emily F. Calderbank, Hugo P. Bastos, Laura Magnani, H. Foster, Kendig Sham, Chenyan Wu, Giovanna Mantica, Carys S. Johnson, Nicole Mende, Daniel Hayler, Stefano Marra, Joakim S. Dahlin, Cédric Ghevaert, Elisa Laurenti

The paper introduces an EPD assay to study human HSC lineage commitment and identifies IL-33 as a regulator of megakaryopoiesis by activating the MAPK pathway.

bioRxiv · Sep 3, 2026 · PreprintCell Biology

DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells

Giovanna Mantica, Aditi Vedi, Amos Tuval, Hector Huerga Encabo, Daniel Hayler, Aleksandra Krzywon, Emily Mitchell, William G. Dunn, Tamir Biezuner, Hugo P. Bastos, Kendig Sham, Antonella Santoro, Joe Lee, Nick Williams, Adi Danin, , Elisa Laurenti

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

bioRxiv · Oct 8, 2025 · PreprintCell Biology

Clonal dynamics of haematopoiesis across the human lifespan

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas J. Mitchell, Tim H. H. Coorens, David H. Spencer, Heather E. Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, , Peter J. Campbell

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

Nature · Jun 1, 2022Peer-reviewedGenomics