Christopher J. Minteer

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

Clustering 5,717 clock CpGs into twelve modules shows that different epigenetic clocks mix those modules in different proportions, and that reprogramming rejuvenates only some of them.

This paper develops a DNA methylation biomarker, DNAmSen, to measure cellular senescence and shows its correlation with age and age-related diseases.