BioinformaticsbioRxivPreprint
SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells
Ana Dominguez Andres, Yongmei Feng, Alexandre Rosa Campos…·Ze’ev A. Ronai
The 73-amino-acid SARS-CoV-2 membrane-associated protein ORF9c suppresses interferon, antigen presentation, and complement pathways while inducing IL-6 signaling in lung epithelial cells, an effect blunted by proteasome or VCP inhibition.
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