Aniruddha J. Deshpande

Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

This paper identifies an acetylation-dependent circuit controlling SEC integrity in AML, showing that disrupting KAT2A/B leads to broad anti-leukemic effects across subtypes.

Automation workflow for high-throughput arrayed plasmid DNA preparation and quantification.

The paper describes an automated workflow for high-throughput plasmid DNA preparation and quantification using a robotic workstation, achieving high yields and quality with minimal human intervention.

Automation of high-throughput workflow for arrayed CRISPR activation library screening

This paper develops an automated high-throughput workflow for arrayed CRISPRa screening, demonstrating its effectiveness in identifying growth reduction phenotypes in HEK293 cells.

Automation of high-throughput arrayed lentivirus production and titration

This paper develops an automated workflow for high-throughput lentivirus production and titration, achieving high reproducibility and efficiency in generating CRISPR libraries.

Automation of high-throughput arrayed mammalian cell line cultivation

This paper automates high-throughput mammalian cell culture workflows using an integrated workstation and software, enabling efficient clonal line establishment.

Nucleosome stability safeguards cell identity, stress resilience and healthy aging

The paper shows that reduced nucleosome stability impairs cell identity, stress resilience, and healthy aging across species.

SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis

This study identifies SUMO2 as a selective vulnerability in synovial sarcoma, showing that SUMO2 inhibition reverses SS18-SSX-driven gene expression and impairs tumor growth.

Towards universal modeling of transcript isoform expression levels

The paper models transcript isoform expression levels using epigenomic data from 324 human samples, showing that a universal model outperforms tissue-specific models.

Targeting the translation initiation complex in therapy-resistant and metastatic melanoma

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity

The paper shows that AF10, a DOT1L interaction partner, regulates H3K79 methylation levels and RNA polymerase II distribution to maintain cell identity and prevent reprogramming.

SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

The 73-amino-acid SARS-CoV-2 membrane-associated protein ORF9c suppresses interferon, antigen presentation, and complement pathways while inducing IL-6 signaling in lung epithelial cells, an effect blunted by proteasome or VCP inhibition.