Bingyang Shi

This study uses upconversion nanoparticles and real-time imaging to visualize vascular permeability changes in zebrafish, revealing distinct transcellular and paracellular transport mechanisms and demonstrating enhanced BBB penetration with functionalized nanoparticles.

This study shows riluzole does not improve disease outcomes in a mouse model of ALS with cytoplasmic TDP-43 pathology.

The paper validates and optimizes Bimolecular Fluorescence Complementation (BiFC) in zebrafish to study ALS-linked protein aggregate formation in vivo.

The paper identifies cyclin F interactors using BioID and shows that ALS/FTD-associated cyclin F mutations disrupt paraspeckle protein homeostasis, particularly RBM14 levels in patient tissue.