Author

Sheng Le

Macquarie UniversityORCID 0000-0003-4757-3466Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adam K. WalkeriD· 2 shared Amanda L. WrightiD· 2 shared Rebecca San GiliD· 2 shared Albert LeeiD· 1 shared Bingyang ShiiD· 1 shared Britt A. BerningiD· 1 shared Catherine A. BlizzardiD· 1 shared Frank RigoiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Adam K. WalkerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NeuroscienceMolecular PsychiatryPeer-reviewedApr 3, 2023

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS/FTD

Wei Luan, Amanda L. Wright, Heledd Brown-Wright…·Adam K. Walker

This study identifies early activation of stress and apoptotic pathways in a mouse model of ALS/FTD and shows that suppressing Chop has limited effects on disease progression.

39 citationstop 2%

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceEuropean Journal of NeurosciencePeer-reviewedAug 13, 2021

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

Amanda L. Wright, Paul A. Della Gatta, Sheng Le…·Adam K. Walker

This study shows riluzole does not improve disease outcomes in a mouse model of ALS with cytoplasmic TDP-43 pathology.

35 citations

mouseproteomics

𝕏 PostBluesky