Audrey Ferrand

This study identifies an osteopontin-enriched secretome in IBD-derived colonic fibroblasts and shows that OPN impairs epithelial maturation in human colonic organoids.

This study shows progastrin activates colonic fibroblasts and promotes CRC cell migration via a PI3K/Akt-dependent paracrine mechanism involving CXCL12 and CXCL8.

This paper develops a method to assess micro-tissue mechanics non-destructively, revealing that stiffness gradients in the tumour microenvironment slow pressure increase during growth.

The paper studies how cell division affects the extracellular matrix in human colonic epithelium organoids using 4D imaging and Digital Volume Correlation.

The paper introduces a human colon microphysiological system that replicates the 3D topography and matrix stiffness of the colon using hydrogels and microfluidic control, enabling long-term culture and imaging of colonic epithelial cells.