Timothy Cragin Wang

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

This paper shows that sensory neurons form long-term inflammatory memory, enhancing gastric regeneration and tumor susceptibility after injury.

This study shows progastrin activates colonic fibroblasts and promotes CRC cell migration via a PI3K/Akt-dependent paracrine mechanism involving CXCL12 and CXCL8.

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

This study shows colibactin-producing E. coli promote GEAC carcinogenesis by increasing proliferation, DNA damage, and cancer pathways, while also inducing autophagy and differentiation.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

The paper identifies Dclk1-expressing cells in the pancreas and reveals their role in inhibiting pancreatic tumor progression through a tuft cell-ILC2 axis.

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

The paper proposes a systems modeling workflow for knowledge discovery in proteomics datasets, applied to pancreatic ductal adenocarcinoma to identify translational targets and pathways.

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

This study evaluates exome sequencing in liver diseases, finding a 5.7% diagnostic rate for monogenic disorders after filtering and manual review.