Author

Dimitri Hamel

Centre National de la Recherche ScientifiqueORCID 0000-0002-9778-5355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:organoid / primary culture· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Audrey FerrandiD· 2 shared Delphine BonnetiD· 1 shared Dior Sambe· 1 shared Duvan Rojas-Garcia· 1 shared Julie FoncyiD· 1 shared Laurent AlriciD· 1 shared Laurent MalaquiniD· 1 shared Muriel Quaranta· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

Audrey FerrandORCID

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2 papers

Recent·Most cited

IBD-Derived Colonic Fibroblasts Exhibit an Osteopontin-Enriched Secretome, and Osteopontin Restrains Human Colonic Organoid Maturation

Dimitri Hamel, Muriel Quaranta, Delphine Bonnet, Laurent Alric, Audrey Ferrand

This study identifies an osteopontin-enriched secretome in IBD-derived colonic fibroblasts and shows that OPN impairs epithelial maturation in human colonic organoids.

bioRxiv · Sep 3, 2026 · PreprintPhysiology

Human Colon Microphysiological System Reproducing Tissue Mechanical Microenvironment With Active Microfluidic Control and Imaging Capacity

Duvan Rojas-Garcia, Dimitri Hamel, Julie Foncy, Dior Sambe, Sandra Pefaure, Laurent Malaquin, Audrey Ferrand

The paper introduces a human colon microphysiological system that replicates the 3D topography and matrix stiffness of the colon using hydrogels and microfluidic control, enabling long-term culture and imaging of colonic epithelial cells.

bioRxiv · Apr 10, 2025 · PreprintBioengineering