Nareg H. Roubinian

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.