Aaron Issaian

The paper investigates the interaction between U1 snRNP and RNA polymerase II in yeast, finding that Prp40, not U1-70K, mediates this interaction, contrasting with the human system.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

The paper identifies a small molecule inhibitor that targets multiple RNA binding proteins, showing its effects are independent of Musashi-2 and provides a framework for validating RBP inhibitor specificity.