Monika Dzieciątkowska

This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.

This study links metabolic and inflammatory changes to arterial stiffness in ultra-endurance runners using multi-omics analysis of plasma samples.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study shows that long-distance trail running causes inflammation, lipid, and purine oxidation in red blood cells, indicating systemic inflammation and metabolic changes as key factors in RBC damage.

This study compares lipid sources in erythroid cultures, finding that detergent-treated plasma leads to cholesterol-deficient reticulocytes with impaired function, while AB-serum supports stable reticulocyte generation.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

This study identifies IRF2BP2 cytoplasmic sequestration by MCL1 as a mechanism driving venetoclax and azacitidine resistance in AML through ACSL1 derepression.

This study identifies molecular and cellular changes in storage-induced senescent erythrocytes (SMEs) that lead to their clearance, showing altered metabolism, proteostasis, and membrane properties.

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

The paper uses proteomics to identify AF components in sponges and finds conserved domains suggesting an ancient toolkit for cell adhesion and allorecognition.

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

This study reveals that calorie restriction's effects on metabolism and molecular processes depend on the timing of measurements relative to feeding, not just diet alone.

This study builds tissue-specific metabolic models for Drosophila to identify metabolic dysregulation in muscle caused by a high sugar diet.