Riikka Lund

The paper evaluates the type 1 error rate in bisulfite sequencing analysis of umbilical cord blood samples and finds that permutation-based significance analysis reduces it, with minimal differential methylation associated with clinical variables except sex.

The paper identifies DNA methylation differences in peripheral blood of Alzheimer’s disease discordant twin pairs, linking these to brain gene expression and neuronal functions.

LuxRep improves methylation level and differentially methylated site estimation by incorporating low bisulfite conversion rate technical replicates in BS-seq analysis.