The paper presents a comprehensive multi-omics dataset of healthy individuals, revealing sex and age influences and providing reference ranges for omics features.

bioRxiv · Nov 7, 2024 · PreprintBioinformatics

Multi-omics Quality Assessment in Personalized Medicine through EATRIS

EATRIS Plus Multi-omics working group and stakeholders (in alphabetical order by last name), Patricia Alonso-Andrés, Davide Baldazzi, Qiaochu Chen, Elisa Conde, Lorena Crespo-Toro, Kati M. Donner, Petr Džubák, Sara Ekberg, Laura García‐Bermejo, Daniela Gasparotto, Bishwa R. Ghimire, Jolein Gloerich, Janine Habier, Marián Hajdúch, , Patricia Žižkovičová

The paper describes EATRIS activities for quality assessment in multi-omics data generation and integration, aiming to support translational medicine through a Multi-Omics Toolbox.

bioRxiv · Oct 25, 2023 · PreprintMolecular Biology

Analysis of human brain tissue derived from DBS surgery

Salla M. Kangas, Jaakko Teppo, Maija Lahtinen, Anu Suoranta, Bishwa R. Ghimire, Pirkko Mattila, Johanna Uusimaa, Markku T Varjosalo, Jani Katisko, Reetta Hinttala

The paper describes a method to collect brain tissue from DBS surgical instruments for transcriptomic and proteomic analysis, showing it provides reliable data comparable to traditional brain tissue samples.

Translational Neurodegeneration · Apr 13, 2022Peer-reviewedNeuroscience

Patient-tailored design of AML cell subpopulation-selective drug combinations

Aleksandr Ianevski, Jenni Lahtela, Komal Kumar Javarappa, Philipp Sergeev, Bishwa R. Ghimire, Prson Gautam, Markus J. V. Vähä-Koskela, Laura Turunen, Nora M Linnavirta, Heikki A Kuusanmäki, Mika Kontro, Kimmo Porkka, Caroline Akemi Heckman, Pirkko Mattila, Krister Wennerberg, , Tero A. Aittokallio

This paper develops a computational-experimental approach to design patient-specific drug combinations for AML that are synergistic and minimally toxic.

Science Advances · Feb 19, 2021Peer-reviewedSystems Biology

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

Mikko Konki, Maia Malonzo, Ida Karlsson, Noora Lindgrén, Bishwa R. Ghimire, Johannes Smolander, Noora M. Scheinin, Miina Ollikainen, Asta Laiho, Laura L. Elo, Tapio Lönnberg, Matias Röyttä, Nancy L. Pedersen, Jaakko A. Kaprio, Harri J Lähdesmäki, , Riikka Lund

The paper identifies DNA methylation differences in peripheral blood of Alzheimer’s disease discordant twin pairs, linking these to brain gene expression and neuronal functions.

Clinical Epigenetics · Sep 2, 2019Peer-reviewedGenomics