Maia Malonzo

LuxHMM segments the genome into regions and infers differential methylation using a hidden Markov model and Bayesian regression, showing competitive performance on real and simulated data.

The paper identifies DNA methylation differences in peripheral blood of Alzheimer’s disease discordant twin pairs, linking these to brain gene expression and neuronal functions.

LuxRep improves methylation level and differentially methylated site estimation by incorporating low bisulfite conversion rate technical replicates in BS-seq analysis.