Orazio Santo Santonocito

From Single-Cell Emergent Behaviors to Clinical Outcome: PTEN-driven Migratory Efficiency as a Potential New Vulnerability in Glioblastoma

This study identifies PTEN gain-of-function mutations as linked to increased migratory efficiency in glioblastoma cells, correlating with poorer patient survival.

Learning and actioning general principles of cancer cell drug sensitivity

The paper develops interpretable models to predict cancer drug sensitivity using transcriptomics data and enhances predictions with large language models, validated on clinical samples.

Metabolic-imaging of human glioblastoma explants: a new precision-medicine model to predict tumor treatment response early

This paper develops a functional precision medicine approach using metabolic imaging to predict glioblastoma treatment response early in ex-vivo organoids, identifying responder and non-responder groups and a new molecular signature.