TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA Genes
Dany S. Sibai, Michel G. Tremblay, Frédéric Lessard, Christophe Tav, Marianne Sabourin‐Félix, Mark D. Robinson, Tom Moss
This study shows TTF1 regulates cell growth by blocking non-coding RNA synthesis from ribosomal gene promoters, thereby suppressing rRNA production and cell proliferation.
bioRxiv · Feb 11, 2024 · PreprintMolecular Biology