Author

Michel G. Tremblay

Université LavalORCID 0000-0003-2545-3682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Tom MossiD· 3 shared Dany S. SibaiiD· 2 shared Frédéric LessardiD· 2 shared Austen R. D. GanleyiD· 1 shared Charles Antony AiD· 1 shared Chelsea L. ThorsheimiD· 1 shared Christophe TaviD· 1 shared Dexter J. Wu-Corts· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMolecular Biology

Tom MossORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 11, 2024

TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA Genes

Dany S. Sibai, Michel G. Tremblay, Frédéric Lessard…·Tom Moss

This study shows TTF1 regulates cell growth by blocking non-coding RNA synthesis from ribosomal gene promoters, thereby suppressing rRNA production and cell proliferation.

1 citation

humanmouse

𝕏 PostBluesky

Molecular BiologyMolecular CellPeer-reviewedSep 15, 2022

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors

Charles Antony A, Subin S. George, Justin Blum…·Vikram R. Paralkar

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

33 citations

humanmouse

𝕏 PostBluesky

Molecular BiologyPLoS GeneticsPeer-reviewedFeb 9, 2022

Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition in cell and is negatively affected in the UBTF-E210K neuroregression syndrome.

Michel G. Tremblay, Dany S. Sibai, Mélissa Valere…·Tom Moss

The paper shows that UBTF1 and SL1 cooperate to enable RNA Polymerase I promoter recognition in rDNA, and this cooperation is disrupted in UBTF-E210K neuroregression syndrome.

22 citations

mousehuman

𝕏 PostBluesky