Tom Moss

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

This study shows TTF1 regulates cell growth by blocking non-coding RNA synthesis from ribosomal gene promoters, thereby suppressing rRNA production and cell proliferation.

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

The paper shows that UBTF1 and SL1 cooperate to enable RNA Polymerase I promoter recognition in rDNA, and this cooperation is disrupted in UBTF-E210K neuroregression syndrome.