Frédéric Lessard

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

This study identifies ZNF768 as a regulator of E2F1 expression, which drives G0/G1 transition and cell cycle progression, with implications for cancer progression.

This study shows TTF1 regulates cell growth by blocking non-coding RNA synthesis from ribosomal gene promoters, thereby suppressing rRNA production and cell proliferation.

The paper shows that UBTF1 and SL1 cooperate to enable RNA Polymerase I promoter recognition in rDNA, and this cooperation is disrupted in UBTF-E210K neuroregression syndrome.

The paper shows that the retinoblastoma protein (RB) prevents ribosomal readthrough during oncogene-induced senescence, acting as a caretaker tumor suppressor.

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.