Pooled screening identifies combinatorial CAR signaling domains for next-generation CAR-M immunotherapies
Yuxin Wang, Shiman Zuo, Hanjing Bao, Zehui Zhang, Yijun Chen, W Zhang, Qi Liu, Yan Lü, Yahong Huang, Wei Hui Zheng, Nanfei Yang, Lupeng Ye, Pingping Shen
The paper identifies combinatorial CAR signaling domains that enhance macrophage function and tumor clearance through pooled screening and single-cell analysis.
bioRxiv · Feb 16, 2025 · PreprintBioengineering