Author
Systems Biology InstituteORCID 0000-0003-3901-6598Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Yuxin Wang, Shiman Zuo, Hanjing Bao…·Pingping Shen
The paper identifies combinatorial CAR signaling domains that enhance macrophage function and tumor clearance through pooled screening and single-cell analysis.
Jonathan Joon-Young Park, Adan Codina, Lupeng Ye…·Sidi Chen
The paper identifies genetic interactions between cancer mutations and immune resistance genes using a CRISPR double knockout screen, revealing potential targets for existing drugs.
Guangchuan Wang, Ryan Dz-Wei Chow, Lupeng Ye…·Sidi Chen
The paper introduces PASTAS, a method for in vivo CRISPR screening in mice, and demonstrates its use in identifying cancer driver variants in liver tumors.
Ryan Dz-Wei Chow, Christopher D. Guzman, Guangchuan Wang…·Sidi Chen
This study uses an AAV-mediated CRISPR screen in mice to identify functional suppressors of glioblastoma, revealing novel and canonical tumor suppressors and their interactions.
Ryan Dz-Wei Chow, Guangchuan Wang, Adan Codina…·Sidi Chen
The paper uses Cpf1 crRNA arrays to map genetic interactions in vivo, identifying novel drivers and co-drivers of cancer transformation and metastasis.