Wei Hui Zheng

Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations

The paper shows that astrocyte activity drives brainwide changes in sensory, integrative, and motor computations during a passive state in zebrafish.

Visualizing the translation landscape in human cells at high resolution

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16

This paper evaluates blind predictions of dynamic water and ion ensembles around RNA using cryo-EM densities from CASP16, finding that molecular dynamics approaches perform best.

StoPred: Accurate Stoichiometry Prediction for ProteinComplexes Using Protein Language Models and GraphAttention

StoPred predicts protein complex stoichiometry using protein language models and graph attention networks, achieving higher accuracy for both homomeric and heteromeric complexes than existing methods.

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

Pooled screening identifies combinatorial CAR signaling domains for next-generation CAR-M immunotherapies

The paper identifies combinatorial CAR signaling domains that enhance macrophage function and tumor clearance through pooled screening and single-cell analysis.

Decoding the Molecular Language of Proteins with Evolla

Evolla, a protein-language model, improves functional inference and discovers novel proteins through natural language queries and benchmarking.

ModelCIF: An extension of PDBx/mmCIF data representation for computed structure models

ModelCIF extends the PDBx/mmCIF standard to represent predicted 3D protein models, enabling FAIR data sharing for computational structural biology.

Evolution of a chordate-specific mechanism for myoblast fusion

The paper investigates the evolutionary origins of myoblast fusion mechanisms in chordates, identifying the emergence of Myomaker and Myomixer and their roles in muscle development across species.

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

This paper introduces DEMO-EM, a method for assembling multi-domain protein structures from cryo-EM maps, achieving high accuracy and outperforming existing methods.

CAT, AGTR2, L-SIGN and DC-SIGN are potential receptors for the entry of SARS-CoV-2 into human cells

The paper identifies potential SARS-CoV-2 receptors, including CAT, AGTR2, L-SIGN, and DC-SIGN, which show higher binding affinity to the S protein than ACE2 and are expressed in affected tissues.

Decoding microbiome and protein family linkage to improve protein structure prediction

The paper improves protein structure prediction by linking microbiome sequences to protein families using a targeted approach with predicted biomes.

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

TripletRes predicts high-accuracy protein contact-maps from primary sequences using deep residual convolutional networks and coevolutionary matrices, outperforming existing methods on benchmark datasets.

Evolution of myoglobin in avian lineages: positive selection for aggregation resistance in penguins and high purifying selection in galliforms

The paper models myoglobin structures in 302 vertebrates, finds positive selection for aggregation resistance in penguin myoglobins and purifying selection in galliforms, and proposes a new equation for net charge and concentration relationship.

Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1

The paper re-analyzes computational findings from two studies, concluding that snakes are not intermediate hosts of 2019-nCoV and that spike protein insertions are naturally evolved from bat coronaviruses.