Zheng Ying

Cooperative IDR-folded domain interplay governs HP1α phase separation and underlies biphasic regulation by pathogenic poly-PR

This study shows that HP1α phase separation is driven by interactions between intrinsically disordered regions and folded domains, not just IDRs alone, and reveals how poly-PR affects this process in a concentration-dependent manner.

Pre-mRNA splicing inhibits m6A deposition, allowing longer mRNA half-life and flexible protein coding