CD14 Blockade Attenuates Arrhythmogenic Cardiomyopathy
Vinay R. Penna, Emily A. Shiel, Waleed Farra…·Kory J. Lavine
This study shows that blocking CD14 reduces arrhythmogenic cardiomyopathy in mice by decreasing inflammation and fibrosis.
Author
Washington University in St. LouisORCID 0000-0002-1118-1535Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
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Vinay R. Penna, Emily A. Shiel, Waleed Farra…·Kory J. Lavine
This study shows that blocking CD14 reduces arrhythmogenic cardiomyopathy in mice by decreasing inflammation and fibrosis.
Yao Li, Christopher Oetheimer, Yuyan Wang…·Ke Zhang
This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.
Junedh Amrute, In‐Hyuk Jung, Tracy Yamawaki…·Kory J. Lavine
Single-cell and spatial maps of human coronary arteries identify FAP as a marker of SMC-derived modulated cells; an anti-FAP BiTE reduced plaque burden in mouse models.
Mean Ghim, Onur Varli, Azmi A. Ahmad…·Mehran M. Sadeghi
This study investigates how aging affects aortic MMP activity and aneurysm development using MMP-targeted imaging, finding increased MMP activity and worse survival in older mice.
Junedh Amrute, Ada Zhu, Yun-Ling Pai…·Kory J. Lavine
This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.
Xu Yang, Dongbin Chen, Shirui Zheng…·Yongping Huang
This study identifies BmHen1 as essential for eupyrene sperm development in B. mori, while PIWI proteins Siwi and BmAgo3 are not involved in this process.
Xu Yang, Dongbin Chen, Shirui Zheng…·Yongping Huang
This study identifies BmPrmt5 and BmVasa as essential regulators of dichotomous spermatogenesis in Bombyx mori, showing their roles in sperm morphology and gene expression through genetic and RNA-seq analyses.