Author

Danielle Pruitt

Amgen (United States)ORCID 0009-0002-8277-8467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ingrid C. RulifsoniD· 3 shared Jose BarredaiD· 3 shared Andrea L. BredemeyeriD· 2 shared Chang Jie Mick LeeiD· 2 shared Chi-Ming LiiD· 2 shared Daniel KreiseliD· 2 shared Jixin Cui· 2 shared Junedh AmruteiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Ingrid C. RulifsonORCID

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3 papers

Recent·Most cited

GenomicsSciencePeer-reviewedJan 29, 2026

✦ In-depth digest

Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

Junedh Amrute, In‐Hyuk Jung, Tracy Yamawaki…·Kory J. Lavine

Single-cell and spatial maps of human coronary arteries identify FAP as a marker of SMC-derived modulated cells; an anti-FAP BiTE reduced plaque burden in mouse models.

37 citationstop 1%

humanmouse

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Cell BiologyCell ReportsPeer-reviewedOct 1, 2025

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory…·Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

9 citationstop 3%

humanmouse

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ImmunologybioRxivPreprintJul 25, 2025

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

Junedh Amrute, Ada Zhu, Yun-Ling Pai…·Kory J. Lavine

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

2 citations

humanscRNA-seq

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