Author

Vinay R. Penna

Washington University in St. LouisORCID 0000-0002-9082-7874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:deconvolution· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elisa Nicole CannoniD· 2 shared Emily A. ShieliD· 2 shared Jeffrey E. SaffitziD· 2 shared Kory J. LavineiD· 2 shared Stephen P. ChelkoiD· 2 shared Waleed Farra· 2 shared Alekhya ParvathaneniiD· 1 shared Ana VillanuevaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Elisa Nicole CannonORCID

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2 papers

Recent·Most cited

CD14 Blockade Attenuates Arrhythmogenic Cardiomyopathy

Vinay R. Penna, Emily A. Shiel, Waleed Farra, Elisa Nicole Cannon, Maicon Landim-Vieira, Macee C. Owen, Rajiu Venkatesan, Gyu Seong Heo, Avash Das, Yongjian Liu, Mark W. Appleby, David. T. Crowe, Brian. W. Ziegelaar, Garry L. Redlich, Jeffrey E. Saffitz, , Kory J. Lavine

This study shows that blocking CD14 reduces arrhythmogenic cardiomyopathy in mice by decreasing inflammation and fibrosis.

bioRxiv · Oct 7, 2026 · PreprintImmunology

Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy

Vinay R. Penna, Junedh Amrute, Morgan Engel, Emily A. Shiel, Waleed Farra, Elisa Nicole Cannon, Colleen Leu-Turner, Pan Ma, Ana Villanueva, Hae-Won Shin, Alekhya Parvathaneni, Joanna Jager, Carlos Bueno‐Betí, Angeliki Asimaki, Kory J. Lavine, , Stephen P. Chelko

Human arrhythmogenic cardiomyopathy hearts harbor a lesion niche of POSTN fibroblasts and NLRP3+ inflammatory macrophages; IL-1β neutralization in Dsg2-mutant mice reduced fibrosis, dysfunction, and ventricular ectopy.

JACC Basic to Translational Science · May 5, 2026Peer-reviewedImmunology✦ In-depth digest