Yuyan Wang

This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.

This paper develops a bottlebrush polymer-conjugated aptamer (pacDNA) to improve aptamer stability and efficacy in targeting AXL, showing reduced cancer cell migration and tumor growth in a xenograft model.

This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.