Author

J. Robert S. Whittle

Cancer Research UK Manchester InstituteORCID 0000-0002-1139-1671Unclaimed ORCID profile · follow to get notified of new preprints

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Jessica Whittle1 paper · University of Manchester

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Georges LacaudiD· 2 shared Duncan L. SmithiD· 1 shared Eve LeddyiD· 1 shared Jingru XuiD· 1 shared Liam ClayfieldiD· 1 shared Michael Lie‐A‐LingiD· 1 shared Mudassar IqbaliD· 1 shared Özgen DeniziD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Georges LacaudORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 12, 2025

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemia

Jingru Xu, Jessica Whittle, Liam Clayfield…·Georges Lacaud

This study identifies IRF2BP2 as a critical regulator of transposable element silencing in AML, showing its loss leads to TE activation and leukemia cell death.

DOI 10.1101/2025.11.12.688028

𝕏 PostBluesky

Cancer BiologybioRxivOct 29, 2024

Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML

J. Robert S. Whittle, Stefan Meyer, Georges Lacaud…·Mudassar Iqbal

The paper integrates scRNA-seq data to create an AML single-cell atlas, revealing age-related gene regulatory networks in t(8;21) AML and identifying BCLAF1 as a prognostic indicator.

2 citations

𝕏 PostBluesky