Georges Lacaud

This study identifies IRF2BP2 as a critical regulator of transposable element silencing in AML, showing its loss leads to TE activation and leukemia cell death.

This study shows that Gfi1 regulates the formation of exhausted effector-like CD8 T cells during chronic infection and cancer, impacting their differentiation and function.

The paper integrates scRNA-seq data to create an AML single-cell atlas, revealing age-related gene regulatory networks in t(8;21) AML and identifying BCLAF1 as a prognostic indicator.

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

This study identifies RUNX1 as a marker for a castration-resistant luminal lineage in the developing and adult mouse prostate, distinct from NKX3.1+ cells.

The paper identifies a new pathway for red blood cell generation in the mouse embryo by discovering hemogenic endothelial cells that can produce erythrocytes independently of Runx1.