Author

Janelle J.Y. Chuah

West Virginia UniversityORCID 0000-0002-1139-694XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

David M. SmithiD· 1 shared Madalena R. DaughertyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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1 shared paperBiochemistry

David M. SmithORCID

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1 paper

Recent·Most cited

BiochemistryeLifePeer-reviewedAug 14, 2025

Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes.

Janelle J.Y. Chuah, Madalena R. Daugherty, David M. Smith

This study identifies the Hb group's interaction with the hydrophobic pocket as sufficient to induce gate opening in archaeal 20S proteasomes, revealing a mechanism for proteasome activation.

2 citations

cryo-EMexperimental assay

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