Author

David M. Smith

West Virginia UniversityORCID 0000-0002-1502-676XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David Salcedo-TacumaiD· 3 shared Aimer Gutierrez-DiaziD· 1 shared Celine BrooksiD· 1 shared Coleman Mchose· 1 shared Douglas R. KolsoniD· 1 shared Emily R. SechrestiD· 1 shared Giovanni HowellsiD· 1 shared Isabella Mascari· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

David Salcedo-TacumaORCID

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Author profile →

4 papers

Recent·Most cited

Mapping the chaperonin TRiC/CCT interactome in mouse photoreceptors reveals functional significance for energy metabolism

Celine Brooks, David Salcedo-Tacuma, Isabella Mascari, Mark Eminhizer, Tuan Ngo, Douglas R. Kolson, Emily R. Sechrest, Tongju Guan, Neil Billington, Wen‐Tao Deng, David M. Smith, Jianhai Du, Nikolai P. Skiba, Maxim Sokolov

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

PLoS ONE · Jul 29, 2026Peer-reviewedBiochemistry

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins.

David Salcedo-Tacuma, Nadeem Asad, Md. Qamrul Islam, Raymond T. Anderson, David M. Smith

This study shows that a hyperactive 20S proteasome in C. elegans improves degradation of misfolded proteins, reduces oxidative damage, and extends lifespan without relying on known proteostasis pathways.

Science Advances · Oct 10, 2025Peer-reviewedCell Biology

Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes.

Janelle J.Y. Chuah, Madalena R. Daugherty, David M. Smith

This study identifies the Hb group's interaction with the hydrophobic pocket as sufficient to induce gate opening in archaeal 20S proteasomes, revealing a mechanism for proteasome activation.

eLife · Aug 14, 2025Peer-reviewedBiochemistry

ProEnd: A Comprehensive Database for Identifying HbYX Motif-Containing Proteins Across the Tree of Life

David Salcedo-Tacuma, Giovanni Howells, Coleman Mchose, Aimer Gutierrez-Diaz, Jane E. Schupp, David M. Smith

ProEnd identifies and catalogs HbYX motif-containing proteins across diverse organisms, revealing their evolutionary conservation and potential role in proteasome interactions.

BMC Genomics · Oct 13, 2024Peer-reviewedCell Biology