Context-dependent toxicity of human Tau isoforms in a Drosophila tauopathy model
Yelena Ivanova, Miguel Ramírez Moreno, Jie Liu, Seyedehleila Abtahi, Baidong Wu, Amber S. Cooper, Zengbo Wang, Douglas W. Allan, Amritpal K. Mudher, Aaron A. Comeault, Lovesha Sivanantharajah
This study shows that human Tau isoforms have context-dependent toxicity in a Drosophila model, with variations in expression timing, tissue type, and neuronal identity affecting degeneration outcomes.
Biology Open · Jul 8, 2026Peer-reviewedNeuroscience