Amber S. Cooper

This study shows that human Tau isoforms have context-dependent toxicity in a Drosophila model, with variations in expression timing, tissue type, and neuronal identity affecting degeneration outcomes.

This paper describes using Drosophila wing discs to study Tau-mediated disease mechanisms and screen for neuroprotective drugs, showing that human Tau causes cell death and that NAP reduces toxicity.

This study shows that Tau aggregation, not phosphorylation, is critical for neurotoxicity in Drosophila, suggesting that targeting aggregation may be more effective than targeting phosphorylation in tauopathies.