Miguel Ramírez Moreno

This study shows that human Tau isoforms have context-dependent toxicity in a Drosophila model, with variations in expression timing, tissue type, and neuronal identity affecting degeneration outcomes.

This paper describes using Drosophila wing discs to study Tau-mediated disease mechanisms and screen for neuroprotective drugs, showing that human Tau causes cell death and that NAP reduces toxicity.

The paper shows E-cadherin endocytosis regulates EGFR:STAT signaling to induce apoptosis and inhibit heterochromatin formation in Drosophila wing discs.

This study shows that Tau aggregation, not phosphorylation, is critical for neurotoxicity in Drosophila, suggesting that targeting aggregation may be more effective than targeting phosphorylation in tauopathies.

This study shows that activating the WldS pathway can prevent tau-mediated axonal degeneration in a Drosophila model, even when initiated after degeneration has started.