Amritpal K. Mudher

Context-dependent toxicity of human Tau isoforms in a Drosophila tauopathy model

This study shows that human Tau isoforms have context-dependent toxicity in a Drosophila model, with variations in expression timing, tissue type, and neuronal identity affecting degeneration outcomes.

The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.

This paper describes using Drosophila wing discs to study Tau-mediated disease mechanisms and screen for neuroprotective drugs, showing that human Tau causes cell death and that NAP reduces toxicity.

Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in Drosophila

This study shows that Tau aggregation, not phosphorylation, is critical for neurotoxicity in Drosophila, suggesting that targeting aggregation may be more effective than targeting phosphorylation in tauopathies.

Tau-mediated axonal degeneration is prevented by activation of the WldS pathway

This study shows that activating the WldS pathway can prevent tau-mediated axonal degeneration in a Drosophila model, even when initiated after degeneration has started.

Age-related changes in Tau and Autophagy in human brain in the absence of neurodegeneration

The paper examines age-related changes in tau and autophagy in cognitively normal individuals without neurodegeneration, finding reduced soluble tau and potential autophagy involvement.

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer's disease and other Tauopathies

This paper develops a peptide inhibitor, RI-AG03, that reduces Tau aggregation in vitro and improves Tauopathy symptoms in Drosophila.