Jacek Czub

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

The paper analyzes G-quadruplex conformational landscapes by evaluating 20,000 unique structures from 128 DNA sequences, revealing that long-distance propeller loops restrict folding and are influenced by G4 helicity.

This study uses coarse-grained simulations to show that hydrophobic mismatch drives lipid reorganization around voltage-gated sodium channels, favoring DIPC over DPPC and cholesterol.

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

This study investigates how xCas9 expands DNA targeting by recognizing alternative PAM sequences through increased flexibility in its PAM-interacting region.

The paper studies two mutations in the zebrafish Kcng4b gene, showing how they affect Kv channel function and lead to distinct developmental defects in ear development.

The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.