Author

Łukasz Nierzwicki

Gdańsk University of TechnologyORCID 0000-0001-9221-8848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:structural biology· 1

Frequent Co-Authors

Jacek CzubiD· 3 shared Bartłomiej TomiczekiD· 2 shared Jarosław MarszałekiD· 2 shared Brenda A. SchilkeiD· 1 shared Elizabeth Anne CraigiD· 1 shared Giulia PalermoiD· 1 shared Igor GrochowinaiD· 1 shared Kazi Amirul HossainiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

Jacek CzubORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintMay 22, 2025

Mechanism and energetics of JDP induced Hsp70's conformational transition towards catalytically active state

Michał Olewniczak, Marcin Pitek, Jacek Czub…·Bartłomiej Tomiczek

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

DOI 10.1101/2025.05.22.655504

structural biologydeep learning

𝕏 PostBluesky

BiophysicseLifePeer-reviewedFeb 10, 2025

Flexibility in PAM Recognition Expands DNA Targeting in xCas9

Kazi Amirul Hossain, Łukasz Nierzwicki, Modesto Orozco…·Giulia Palermo

This study investigates how xCas9 expands DNA targeting by recognizing alternative PAM sequences through increased flexibility in its PAM-interacting region.

4 citations

experimental assayprotein folding & dynamics

𝕏 PostBluesky

Molecular BiologyPLoS Computational BiologyPeer-reviewedJun 1, 2020

Two-step mechanism of J-domain action in driving Hsp70 function

Bartłomiej Tomiczek, Wojciech Delewski, Łukasz Nierzwicki…·Jarosław Marszałek

The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.

36 citations

statistical modelexperimental assay

𝕏 PostBluesky